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Journal of Crohn's and Colitis: 9 (8)


Laurence J. Egan, Ireland

Associate Editors

Maria T. Abreu, USAShomron Ben-Horin, IsraelSilvio Danese, ItalyPeter Lakatos, HungaryMiles Parkes, UKGijs van den Brink, NLSéverine Vermeire, Belgium


Published on behalf of

Microinflammation in patients with Crohn's disease in clinical remission

Nitsan Maharshak, Liaz Zilberman, Yaron Arbel, Itzhak Shapira, Shlomo Berliner, Nadir Arber, Iris Dotan
DOI: http://dx.doi.org/10.1016/j.crohns.2008.05.001 310-314 First published online: 1 December 2008


Background and aims: It is not clear whether Crohn's disease patients in clinical remission (Crohn's disease activity index < 150) display normal concentrations of inflammation sensitive biomarkers. Our goal in this work was to explore the intensity of the microinflammatory response in a group of Crohn's disease patients in clinical remission.

Methods: High sensitivity C-reactive protein, quantitative fibrinogen, erythrocyte sedimentation rate as well as platelet and leukocyte counts were examined in a group of 76 patients with Crohn's disease in remission and in 228 matched controls.

Results: Crohn's disease patients in clinical remission displayed a statistically significant (p < 0.001) elevated concentration of hs-CRP (4.83 ± 3.8 mg/l) compared to controls (1.05 ± 2.9 mg/l). All other bio-markers were also significantly higher in Crohn's disease patients in remission compared to controls. Similar results were obtained in a subgroup of Crohn's disease patients with very low disease activity — CDAI < 75.

Conclusions: Clinical remission is not equivalent to biochemical remission raising a question concerning the true definition of remission in Crohn's disease.

  • Crohn's disease
  • Remission
  • Inflammatory markers
  • Abbreviations
    body mass index
    Crohn's disease
    Crohn's disease activity index
    high sensitivity C-reactive protein
    ischemic heart disease
    ulcerative colitis.
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