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Journal of Crohn's and Colitis: 9 (10)


Laurence J. Egan, Ireland

Associate Editors

Maria T. Abreu, USAShomron Ben-Horin, IsraelSilvio Danese, ItalyPeter Lakatos, HungaryMiles Parkes, UKGijs van den Brink, NLSéverine Vermeire, Belgium


Published on behalf of

Oral lichen planus after certolizumab pegol treatment in a patient with Crohn's disease

Filippo Mocciaro, Ambrogio Orlando, Sara Renna, Maria Rosa Rizzuto, Mario Cottone
DOI: http://dx.doi.org/10.1016/j.crohns.2011.01.003 173-174 First published online: 1 April 2011

Dear Sir,

Lichen planus (LP) is a relatively uncommon inflammatory dermatosis of the mucocutaneous surfaces that can present with a variety of clinical manifestations and, most commonly, affecting middle-aged adults. The disease course may be short or chronic, although most cases may resolve after 1 month to 7 years. The real prevalence of LP is unknown, but is estimated to be 1% in the USA.1 The pathogenesis of LP is not entirely understood. In general, activated T lymphocytes are recruited to the dermal–epidermal junction and induce apoptosis in basal keratinocytes. Both CD4+ and CD8+ T lymphocytes are found in the lichenoid infiltrate of LP, with a predominance of the latter cell type being present in established lesions.1

Ten to 20% of patients with LP demonstrate both oral and cutaneous lesions. Oral lichen planus (OLP) manifestations occur in approximately 2% of the general population, while cutaneous lesions occur in 0.4%. We report a rare …

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