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Journal of Crohn's and Colitis: 9 (3)

Editor-in-Chief

Laurence J. Egan, Ireland

Associate Editors

Maria T. Abreu, USAShomron Ben-Horin, IsraelSilvio Danese, ItalyPeter Lakatos, HungaryMiles Parkes, UKGijs van den Brink, NLSéverine Vermeire, Belgium

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Health-related quality of life and disability in patients with ulcerative colitis and proctocolectomy with ileoanal pouch versus treatment with anti-TNF agents

Simone Meijs , Tjibbe J. Gardenbroek , Mirjam A.G. Sprangers , Willem A. Bemelman , Christianne J. Buskens , Geert R.A.M. D’Haens , Mark Löwenberg
DOI: http://dx.doi.org/10.1016/j.crohns.2013.12.011 686-692 First published online: 1 July 2014

Abstract

Background and aims We compared health-related quality of life (HRQL) and disability in ulcerative colitis (UC) patients in remission with anti-tumor necrosis factor agents (TNF) or after restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA).

Methods Two patient cohorts were studied. The first group consisted of patients in remission after RPC with IPAA (surgery group). The second group consisted of patients in remission with infliximab or adalimumab (medical group). For inclusion in the surgery group the pouch had to be functional for ≥ 1 year and patients were excluded in case of postoperative complications. In the medical group, patients had to be on maintenance therapy with anti-TNF agents for ≥ 1 year and in clinical remission. HRQL and disability outcomes were assessed using SF-36, COREFO, WPAI:UC and EORTC questionnaires.

Results 60 patients were included, 30 patients in both groups. 58 out of 60 patients (97%) returned the completed questionnaires: 29 patients in the surgery group (median age 42 years [22–67]; 48% female) and 29 patients in the medical group (median age 45 years [19–68]; 65% female). Patient characteristics were comparable between the two groups. There were no significant differences in SF-36, WPAI:UC and EORTC questionnaires between both groups, except for the medication and stool frequency scale (COREFO questionnaire) that was significantly higher in the surgery vs. the medical group (p= 0.004 and p< 0.001, respectively).

Keywords
  • Anti-TNF agents
  • Disability
  • Health-related quality of life
  • Restorative proctocolectomy
  • Ulcerative colitis
  • Work productivity
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