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Journal of Crohn's and Colitis: 9 (5)

Editor-in-Chief

Laurence J. Egan, Ireland

Associate Editors

Maria T. Abreu, USAShomron Ben-Horin, IsraelSilvio Danese, ItalyPeter Lakatos, HungaryMiles Parkes, UKGijs van den Brink, NLSéverine Vermeire, Belgium

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Intestinal anti-inflammatory activity of the Serpylli herba extract in experimental models of rodent colitis

Francesca Algieri , Alba Rodriguez-Nogales , Natividad Garrido-Mesa , Pedro Zorrilla , Natalie Burkard , Ivo Pischel , Hartwig Sievers , Birgit Benedek , Björn Feistel , Bernd Walbroel , Mª. Elena Rodriguez-Cabezas , Julio Galvez
DOI: http://dx.doi.org/10.1016/j.crohns.2013.12.012 775-788 First published online: 1 August 2014

Abstract

Introduction Nowadays, there is an increasing interest for alternative options in the treatment of inflammatory bowel diseases (IBDs) that combine efficacy and an adequate safety profile.

Methods The intestinal anti-inflammatory effects of Serpylli herba, the officinal drug in the European Pharmacopeia composed by the aerial parts of wild thyme (Thymus serpyllum), were evaluated in the trinitrobenzenesulfonic acid (TNBS)-induced rat colitis and dextran sodium sulfate (DSS)-induced mouse colitis, which are well characterized experimental models with some resemblance to human IBD.

Results S. herba extract exerted an intestinal anti-inflammatory effect in both experimental models of colitis, as evidenced both histologically, since it facilitated the tissue recovery of the damaged colon, and biochemically as showed by the improvement of the different inflammatory markers evaluated, including myeloperoxidase activity, glutathione content, and leukotriene B4 levels as well as the expression of the inducible proteins iNOS and COX-2. This beneficial effect was associated with the reduction in the expression of different cytokines, like TNFα, IL-1β, IFNγ, IL-6 and IL-17, the chemokine MCP-1, and the adhesion molecule ICAM-1, thus ameliorating the altered immune response associated with the colonic inflammation.

Conclusion S. herba extract displays an anti-inflammatory effect on different models of rodent colitis that could be attributed to its immunomodulatory properties.

Keywords
  • DSS mouse colitis
  • Serpylli herba;
  • Thymus serpyllum;
  • TNBS rat colitis
  • Intestine anti-inflammatory activity
  • Abbreviations
    Abbreviation Expansion
    COX-2
    cyclooxygenase-2
    DSS
    dextran sulfate sodium
    GSH
    glutathione
    IBD
    inflammatory bowel disease
    ICAM-1
    intercellular adhesion molecule-1
    IFNγ
    interferon γ
    IL
    interleukin
    iNOS
    inducible nitric oxide synthase
    LTB4
    leukotriene B4
    MCP-1
    monocyte chemotactic protein-1
    MPO
    myeloperoxidase
    TNBS
    trinitrobenzenesulfonic acid
    TNFα
    tumor necrosis factor α
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